Soft tissue myoepithelial carcinoma

Soft tissue myoepithelial carcinoma

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Background.Myoepitheliomas are tumors composed predominantly or exclusively of myoepithelial cells, usually arising in salivary glands.Cutaneous/soft tissue localization is very rare, especially for the malignant myoepitheliomas.

Case report.We presented a case of myoepithelial carcinoma involving subcutaneous adipose tissue of the left forearm in a woman aged 62 years.The tumor was composed of epithelioid and hyaline cell types, arranged Diabetes Monitoring - Glucose Meter Controls in diffuse sheets, nests and loose clusters within hyalinized and myxoid matrix.

The neoplasm displayed high-grade cytologic atypia with some cells having pleomorphic, hyperchromatic nuclei, and others showing vesicular nuclei, large nucleoli with scattered bizarre giant cells.High mean mitotic Mirrors count of 7 mitoses/10 high power fields and extensive necrosis favored the diagnosis of malignancy.Immunohistochemical staining was positive for cytokeratin (AE1/AE3), epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, and vimentin.

Conclusion.Considering the subcutaneous localization, myoepithelial immunophenotype and high-grade cytologic atypia the neoplasm was classified as a soft-tissue myoepithelial carcinoma.